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            首頁(yè) > 新聞中心 > signalchemlifesciences
            
          
            
			        
            
       	  
            signalchemlifesciences
            
           
            
  　更新時(shí)間：2017-04-12　點(diǎn)擊量：2063
         
            
          
            
        
            signalchemlifesciences——激酶研究
            SignalChem Lifesciences Corporation (“SLC”)公司總部位于加拿大不列顛哥倫比亞，是激酶研究領(lǐng)域的企業(yè)，其兩大核心產(chǎn)品系列為生物試劑及研究服務(wù)與藥物研發(fā)服務(wù)部。生物試劑及研究服務(wù)（SignalChem Pharmaceuticals Inc）始于2004年，致力于研發(fā)和生產(chǎn)生物醫(yī)藥研究和藥物研發(fā)領(lǐng)域的激酶產(chǎn)品，目前擁有的激酶/表觀遺傳相關(guān)酶類及其檢測(cè)試劑產(chǎn)品超過(guò)2000種，覆蓋幾乎所有激酶靶點(diǎn)以及表觀遺傳研究相關(guān)酶類，以及多種信號(hào)蛋白相關(guān)產(chǎn)品。同時(shí)，為輔助檢測(cè)激酶及臨床疾病和個(gè)體化治療，SignalChem還在生物標(biāo)志物及診斷試劑盒領(lǐng)域有著數(shù)十年的積淀，擁有強(qiáng)大和豐富的相關(guān)產(chǎn)品。藥物研發(fā)服務(wù)部致力于尋找新的小分子激酶抑制劑，并用于臨床治療。憑借公司豐富的激酶特異性小分子復(fù)合物資源庫(kù)，以及公司在激酶研究領(lǐng)域強(qiáng)大研究團(tuán)隊(duì)和豐富研究經(jīng)驗(yàn)，SLC在以激酶及其通路為靶點(diǎn)的藥物設(shè)計(jì)、研發(fā)和生產(chǎn)具有*優(yōu)勢(shì)，目前公司已擁有大量的以激酶為靶點(diǎn)的小分子抑制劑產(chǎn)品，可用于研究各種腫瘤等疾病。蛋白激酶是聯(lián)結(jié)所有細(xì)胞活動(dòng)的中樞，通過(guò)過(guò)表達(dá)/過(guò)度激活及突變蛋白激酶可導(dǎo)致機(jī)體功能異常進(jìn)而引發(fā)疾病，因此靶向激酶的藥物有著重要的臨床應(yīng)用價(jià)值。蛋白激酶家族是僅次于G蛋白偶聯(lián)受體家族的第二大藥物靶點(diǎn)，目前已發(fā)現(xiàn)約518種野生型的激酶族以及與其相關(guān)的臨床突變案例，有超過(guò)30種FDA認(rèn)證的激酶抑制劑。憑借著多年來(lái)以激酶為核心的細(xì)胞信號(hào)相關(guān)產(chǎn)品研發(fā)積累，以及為科研院所及制藥企業(yè)科研服務(wù)經(jīng)驗(yàn)，SignalChem在抑制激酶活性的藥物領(lǐng)域處于水平，公司不僅擁有zui大的且不斷成長(zhǎng)的活性激酶及突變激酶產(chǎn)品線，以及可在多個(gè)檢測(cè)平臺(tái)實(shí)施的激酶活性檢測(cè)試劑盒，而且不斷與多個(gè)大型制藥企業(yè)和研究院所廣泛合作，公司的主要產(chǎn)及服務(wù)包括：
            1、憑借公司強(qiáng)大的科研力量和經(jīng)驗(yàn)，SignalChem推出的“Kinome Search Engine”激酶篩選系統(tǒng)，可對(duì)每一個(gè)激酶族中的單個(gè)激酶做出檢測(cè)，從而輔助和加快激酶藥物的研發(fā)。
            2、“Kinome Search Engine”激酶篩選系統(tǒng)不僅可輔助設(shè)計(jì)激酶藥物，還可進(jìn)一步研究人類激酶族的功能和機(jī)制，加深對(duì)未知激酶的認(rèn)識(shí)，尋找更多的藥物靶點(diǎn)，（目前認(rèn)證的藥物僅僅有少于5%是以已知的激酶通路為靶點(diǎn)，因此激酶通路作為藥物靶點(diǎn)有著巨大的潛力和價(jià)值）。
            3、SignalChem公司擁有激酶相關(guān)臨床突變數(shù)據(jù)庫(kù)，在研究疾病復(fù)發(fā)和抗藥領(lǐng)域的核心問(wèn)題時(shí)有著的優(yōu)勢(shì)，可以更為有效地協(xié)助制藥企業(yè)進(jìn)行藥物研發(fā)。
            除了藥物研發(fā)方面的優(yōu)勢(shì)，SignalChem還在生物標(biāo)志物及診斷試劑盒領(lǐng)域有著數(shù)十年的積淀，擁有強(qiáng)大和豐富的相關(guān)產(chǎn)品。
            目前SLC公司的產(chǎn)品覆蓋了幾乎所有細(xì)胞內(nèi)激酶相關(guān)通路，包括AKT/PKB通路、ERK/MAPK通路、JAK/STAT通路、JNK/SAPK通路、NfkB通路、p38通路、PKA/PKC通路、WNT信號(hào)通路等，適用于血管再生、凋亡和自噬、腫瘤、心血管疾病、細(xì)胞周期、細(xì)胞應(yīng)激、胞內(nèi)酪氨酸激酶、炎癥、浸潤(rùn)和轉(zhuǎn)移、脂質(zhì)激酶、代謝性疾病、神經(jīng)生物學(xué)、磷酸酶/磷酸二酯酶、受體酪氨酸激酶、Ser/Thr激酶等研究領(lǐng)域。主要產(chǎn)品有：
             
            一、蛋白酶類產(chǎn)品系列
             1、高活性乙酰轉(zhuǎn)移酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            KAT2A (GCN5), Active
            K311-381G
            Human
            GST tag
            Sf9 insect cells
            323-end
            NM_021078
            KAT2B (PCAF), Active
            K311-381BG
            Human
            GST tag
            Sf9 insect cells
            431-end
            NM_003884
            KAT3A (CREBBP), Active
            K312-381G
            Human
            GST tag
            Sf9 insect cells
            1319-1710
            NM_004380
            KAT5 (TIP60), Active
            K314-380G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_006388
            KAT6B (MYST4), Active
            K315-381BG
            Human
            GST tag
            Sf9 insect cells
            431-end
            NM_012330
            KAT7 (MYST2), Active
            K316-380G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_007067
             
            2、高活性精氨酸脫亞氨酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            PAD Cocktail, Active
            P312-37C
            -
            -
            -
            Full Length
            -
                  
            3、高活性GTP/ATP酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            CDC42, Active
            C108-310GH
            Human
            GST/His
            E.coli
            Full length
            NM_001791
            GNAI1, Active 
            G121-310G
            Human
            GST tag
            E.coli
            2-end
            NM_002069
            GNAI2, Active 
            G122-310G
            Human
            GST tag
            E.coli
            2-end
            NM_002070
            GNAI3, Active 
            G123-310G
            Human
            GST tag
            E.coli
            2-end
            NM_006496
            GNAS, Active 
            G127-310G
            Human
            GST tag
            E.coli
            Full length
            NM_000516
            HRAS1 (Mature form), Active
            R105-310H
            Human
            His tag
            E.coli
            2-186
            NM_005343
            KRAS (Mature form), Active
            R106-310H
            Human
            His tag
            E.coli
            2-186
            NM_033360
            NRAS (Mature form), Active
            R107-310H
            Human
            His tag
            E.coli
            2-186
            NM_002524
            RAC1, Active
            R103-310G
            Human
            GST tag
            E.coli
            Full length
            NM_006908
            RAC2, Active
            R104-310H
            Human
            His tag
            E.coli
            Full length
            NM_002872
            RAC3, Active
            R102-310H
            Human
            His tag
            E.coli
            Full length
            NM_005052
            RhoA (Mature form), Active
            R144-310H
            Human
            His tag
            E.coli
            1-190
            NM_001664
            RhoC (Mature form), Active
            R144-310CH
            Human
            His tag
            E.coli
            1-190
            NM_175744
            RhoD (Mature form), Active
            R144-310DH
            Human
            His tag
            E.coli
            1-207
            BC001338
            VCP, Active 
            V116-310G
            Human
            GST tag
            Sf9 insect cells
            Full length
            NM_007126
                  
            4、高活性組蛋白去乙酰化酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            HDAC1, Active
            H83-30G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_004964
            HDAC10, Active
            H92-31G
            Human
            GST tag
            Sf9 insect cells
            1-482
            NM_032019
            HDAC11, Active
            H93-30G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_024827
            HDAC2, Active
            H84-30G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_001527
            HDAC3, Active
            H85-30G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_003883
            HDAC3/NCOR2, Active
            H85-38G
            Human
            GST tags
            Sf9 insect cells
            HDAC3 (full-length)/
            NCOR2 (237-489)
            NM_003883
            HDAC4, Active
            H86-31G
            Human
            GST tag
            Sf9 insect cells
            612-end
            NM_006037
            HDAC5, Active
            H87-31G
            Mouse
            GST tag
            Sf9 insect cells
            617-end
            BC060609
            HDAC6, Active
            H88-30G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            BC069243
            HDAC7, Active
            H89-31G
            Human
            GST tag
            Sf9 insect cells
            501-end
            NM_015401
            HDAC8, Active
            H90-30H
            Human
            His tag
            Sf9 insect cells
            Full Length
            BC050433
             
            5、活性突變激酶（共計(jì)253種）
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            ABL1 Mutant (E255K), Active
            A03-12BG
            Human
            GST tag
            Sf9 insect cells
            27-end (E255K)
            NM_005157
            ABL1 Mutant (E255V), Active
            A03-12HH
            Human
            His tag
            Sf9 insect cells
            27-end (E255V)
            NM_005157
            ABL1 Mutant (F317I), Active
            A03-12JG
            Human
            GST tag
            Sf9 insect cells
            27-end (F317I)
            NM_005157
            ABL1 Mutant (F317L), Active
            A03-12IG
            Human
            GST tag
            Sf9 insect cells
            27-end (F317L)
            NM_005157
            ABL1 Mutant (G250E), Active
            A03-12CG
            Human
            GST tag
            Sf9 insect cells
            27-end (G250E)
            NM_005157
            ABL1 Mutant (H396P), Active
            A03-12LG
            Human
            GST tag
            Sf9 insect cells
            27-end (H396P)
            NM_005157
            ABL1 Mutant (M351T), Active
            A03-12KG
            Human
            GST tag
            Sf9 insect cells
            27-end (M351T)
            NM_005157
            ABL1 Mutant (Q252H), Active
            A03-12FG
            Human
            GST tag
            Sf9 insect cells
            27-end (Q252H)
            NM_005157
            ABL1 Mutant (T315I), Active
            A03-12DG
            Human
            GST tag
            Sf9 insect cells
            27-end (T315I)
            NM_005157
            ABL1 Mutant (V299L), Active
            A03-12MG
            Human
            GST tag
            Sf9 insect cells
            27-end (V299L)
            NM_005157
            ABL1 Mutant (Y253F), Active
            A03-12EG
            Human
            GST tag
            Sf9 insect cells
            27-end (Y253F)
            NM_005157
            ABL1 Mutant (Y253H), Active
            A03-12GH
            Human
            His tag
            Sf9 insect cells
            27-end (Y253H)
            NM_005157
            AKT1 Mutant (E17K), Active
            A16-12G
            Human
            GST tag
            Sf9 insect cells
            Full length (E17K)
            NM_005163
            AKT2 Mutant (E17K), Active
            A17-12G
            Human
            GST tag
            Sf9 insect cells
            Full length (E17K)
            NM_001626
            AKT2 Mutant (R274H), Active
            A17-12BG
            Human
            GST tag
            Sf9 insect cells
            Full length (R274H)
            NM_001626
            AKT3 Mutant (E17K), Active
            A18-12G
            Human
            GST tag
            Sf9 insect cells
            Full Length (E17K)
            NM_005465
            AKT3 Mutant (G171R), Active
            A18-12BG
            Human
            GST tag
            Sf9 insect cells
            Full length (G171R)
            NM_005465
            ALK Mutant (C1156Y), Active
            A19-12DG
            Human
            GST tag
            Sf9 insect cells
            1060-end (C1156Y)
            NM_004304
            ALK Mutant (F1174L), Active
            A19-12EG
            Human
            GST tag
            Sf9 insect cells
            1060-end (F1174L)
            NM_004304
            ALK Mutant (F1174S), Active
            A19-12FG
            Human
            GST tag
            Sf9 insect cells
            1060-end (F1174S)
            NM_004304
            ALK Mutant (G1202R), Active
            A19-12HG
            Human
            GST tag
            Sf9 insect cells
            1060-end (G1202R)
            NM_004304
            ALK Mutant (G1269A), Active
            A19-12JG
            Human
            GST tag
            Sf9 insect cells
            1060-end (G1269A)
            NM_004304
            ALK Mutant (G1269S), Active
            A19-12KG
            Human
            GST tag
            Sf9 insect cells
            1060-end (G1269S)
            NM_004304
            ALK Mutant (L1152R), Active
            A19-12CG
            Human
            GST tag
            Sf9 insect cells
            1060-end (L1152R)
            NM_004304
            ALK Mutant (L1196M), Active
            A19-12GG
            Human
            GST tag
            Sf9 insect cells
            1060-end (L1196M)
            NM_004304
            ALK Mutant (R1275Q), Active
            A19-12LG
            Human
            GST tag
            Sf9 insect cells
            1060-end (R1275Q)
            NM_004304
            ALK Mutant (S1206R), Active
            A19-12IG
            Human
            GST tag
            Sf9 insect cells
            1060-end (S1206R)
            NM_004304
            ALK Mutant (T1151M), Active
            A19-12BG
            Human
            GST tag
            Sf9 insect cells
            1060-end (T1151M)
            NM_004304
            ALK Mutant (T1151_L1152insT), Active
            A19-12G
            Human
            GST tag
            Sf9 insect cells
            1060-end (T1151_L1152insT)
            NM_004304
            ALK2 Mutant (PF197_198L), Active
            A06-12FG
            Human
            GST tag
            Sf9 insect cells
            147-end (PF197_198L)
            NM_001105
            ALK2 Mutant (Q207D), Active
            A06-13CG
            Human
            GST tag
            Sf9 insect cells
            147-end (Q207D)
            NM_001105
            ALK2 Mutant (Q207E), Active
            A06-13DG
            Human
            GST tag
            Sf9 insect cells
            147-end (Q207E)
            NM_001105
            ALK2 Mutant (R206H), Active
            A06-12BG
            Human
            GST tag
            Sf9 insect cells
            147-end (R206H)
            NM_001105
            ALK3 Mutant (Q233D), Active
            B04-12BG
            Human
            GST tag
            Sf9 insect cells
            187-end (Q233D)
            NM_004329
            ALK3 Mutant (R486Q), Active
            B04-12CG
            Human
            GST tag
            Sf9 insect cells
            187-end (R486Q)
            NM_004329
            AXL Mutant (R499C), Active
            A34-12BG
            Human
            GST tag
            Sf9 insect cells
            473-end (R499C)
            NM_021913
            BCR-RET Mutant, Active
            R02-19EG
            Human
            GST tag
            Sf9 insect cells
            1-426 (BCR) - 713-end (RET)
            BC066122
            BRAF Mutant (d485-489 P490Y), Active
            B08-12IG
            Human
            GST tag
            Sf9 insect cells
            381-end or exon 9-18 (d485-489 P490Y)
            NM_004333
            BRAF Mutant (G464V), Active
            B08-12JG
            Human
            GST tag
            Sf9 insect cells
            381-end or exon 9-18 (G464V)
            NM_004333
            BRAF Mutant (G469A), Active
            B08-12FG
            Human
            GST tag
            Sf9 insect cells
            381-end or exon 9-18 (G469A)
            NM_004333
            BRAF Mutant (K601E), Active
            B08-12BG
            Human
            GST tag
            Sf9 insect cells
            416-end (K601E)
            NM_004333
            BRAF Mutant (L597V), Active
            B08-12HG
            Human
            GST tag
            Sf9 insect cells
            381-end or exon 9-18 (L597V)
            NM_004333
            BRAF Mutant (R506_K507insVLR), Active
            B08-13CG
            Human
            GST tag
            Sf9 insect cells
            381-end or exon 9-18 (R506_K507insVLR)
            NM_004333
             
            6、活性激酶
            該產(chǎn)品系列共包括445種激酶產(chǎn)品，下表僅列部分.
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            ABL1, Active
            A03-11H
            Mouse
            His tag
            Sf9 insect cells
            27-end
            NM_009594
            ABL1, Active
            A03-18H
            Human
            His tag
            Sf9 insect cells
            27-end
            NM_005157
            ABL2, Active
            A04-11H
            Human
            His tag
            Sf9 insect cells
            38-end
            NM_005158
            ACK, Active
            A05-11G
            Human
            GST tag
            Sf9 insect cells
            110-476
            NM_005781
            AKT1, Active
            A16-10G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_005163
            AKT2, Active
            A17-10H
            Human
            His tag
            Sf9 insect cells
            Full Length
            NM_001626
            AKT2, Active
            A17-10G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_001626
            AKT3, Active
            A18-10G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_005465
             
            7、高活脂質(zhì)激酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            DGKA, Active 
            D21-10G
            Human
            GST tag
            Sf9 insect cells
            Full length
            NM_001345
            PI3K (p110 alpha (E545K)/p85 alpha), Active 
            P27-152H
            Human
            His tags
            Sf9 insect cells
            Full length
            NM_006218
            PI3K (p110 alpha (N345K(/p85 alpha), Active 
            P27-122CH
            Human
            His tags
            Sf9 insect cells
            Full length
            NM_006218
            PI3K (p110 alpha(E542K)/p85 alpha, Active 
            P27-122DH
            Human
            His tags
            Sf9 insect cells
            Full length
            NM_006218
            PI3K (p110 alpha/p55 gamma), Active 
            P27-102CH
            Human
            His tag
            Sf9 insect cells
            Full length
            NM_006218
            PI3K (p110 alpha/p85 alpha), Active 
            P27-102G
            Human
            GST tags
            Sf9 insect cells
            Full length
            NM_006218
            PI3K (p110 alpha/p85 alpha), Active 
            P27-102H
            Human
            His tags
            Sf9 insect cells
            Full length
            NM_006218
            PI3K (p110 alpha/p85 alpha), Active 
            P27-182H
            Mouse
            His tags
            Sf9 insect cells
            Full length
            NM_008839
            PI3K (p110 beta/p85 alpha), Active 
            P28-102H
            Human
            His tags
            Sf9 insect cells
            Full length
            NM_006219
            PI3K (p110 beta/p85 beta), Active 
            P28-102BH
            Human
            His tags
            Sf9 insect cells
            Full length
            NM_006219
            PI3K (p110 delta/p85 alpha), Active 
            P30-102H
            Human
            His tags
            Sf9 insect cells
            Full length
            NM_005026
            PI3K (p120 gamma), Active 
            P29-102H
            Human
            His tag
            Sf9 insect cells
            Full length
            NM_002649
            PI4K2A, Active 
            P21-102G
            Human
            GST tag
            Sf9 insect cells
            Full length
            NM_018425
            PI4K2B, Active 
            P22-102G
            Human
            GST tag
            Sf9 insect cells
            Full length
            NM_018323
            PI4KA, Active 
            P31-102G
            Human
            GST tag
            Sf9 insect cells
            Full length
            NM_002650
            PI4KB, Active 
            P32-102G
            Human
            GST tag
            Sf9 insect cells
            Full length
            BC000029
            PIK3C2A, Active 
            P23-112G
            Human
            GST tag
            Sf9 insect cells
            299-end
            NM_002645
            PIK3C2B, Active 
            P24-112BG
            Human
            GST tag
            Sf9 insect cells
            850-end
            BC144342
             
            8、高活性甲基轉(zhuǎn)移酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            COMT, Active
            C339-381G
            Human
            GST tag
            Sf9 insect cells
            27-271
            NM_000754
            DNMT3A, Active
            D353-380G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            BC043617
            DNMT3B, Active
            D353-380BG
            Human
            GST tag
            Sf9 insect cells
            Full Length
            BC111933
            DNMT3L, Active
            D353-380CG
            Human
            GST tag
            Sf9 insect cells
            Full Length
            BC002560
            DOT1L (KMT4), Active 
            D344-381G
            Human
            GST tag
            Sf9 insect cells
            1-435
            NM_032482
            EHMT1 (KMT1D), Active 
            E317-381G
            Human
            GST tag
            Sf9 insect cells
            895-end
            NM_024757
            EHMT2, Active
            E318-381G
            Human
            GST tag
            Sf9 insect cells
            807-end
            NM_006709
            LCMT1, Active 
            L321-380G
            Human
            GST tag
            Sf9 insect cells
            Full length
            NM_016309
            MLL1 (KMT2A), Active 
            M341-381G
            Human
            GST tag
            Sf9 insect cells
            3738-end
            NM_005933
            MLL2 (KMT2D), Active 
            M342-381G
            Human
            GST tag
            Sf9 insect cells
            5317-end
            NM_003482
            MLL3 (KMT2C), Active 
            M343-381G
            Human
            GST tag
            Sf9 insect cells
            4689-end
            NM_170606
             
            9、高活性磷酸酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            CDC2, Active
            C04-20G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_001789
            CDC25B, Active
            C04-20BG
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_021873
            CDC25C, Active
            C04-20CG
            Human
            GST tag
            Sf9 insect cells
            Full Length
            BC019089
            DUSP22 (MKPX), Active
            D22-20G
            Human
            GST tag
            E.coli
            Full Length
            NM_020185
            PP1A, Active
            P13-20G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_002708
            PP1B, Active
            P14-20G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_002709
            PP2A alpha/PPP2R1A Complex, Active
            P16-20BH
            Human
            His tags
            Sf9 insect cells
            Full length
            NM_002715
            PP2Aalpha, Active
            P16-20G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_002715
             
            10、高活性磷酸二酯酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            基因號(hào)
            PDE10A, Active
            P98-31G
            Human
            GST tag
            Sf9 insect cells
            71-end
            NM_006661
            PDE1A, Active
            P89-30H
            Human
            His tag
            Sf9 insect cells
            Full Length
            NM_005019
            PDE1B, Active
            P89-30BG
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_000924
            PDE1C, Active
            P89-30CG
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_005020
            PDE2A, Active
            P90-30G
            Human
            GST tag
            Sf9 insect cells
            Full Length
            NM_002599
            PDE3A, Active
            P91-31G
            Human
            GST tag
            Sf9 insect cells
            669-end
            NM_000921
            PDE3B, Active
            P91-31BG
            Human
            GST tag
            Sf9 insect cells
            654-end
            NM_000922
            PDE4A, Active
            P92-31G
            Human
            GST tag
            Sf9 insect cells
            332-end
            NM_001111307
            PDE4B, Active
            P92-31BG
            Human
            GST tag
            Sf9 insect cells
            305-end
            NM_002600
            PDE4C, Active
            P92-31CG
            Human
            GST tag
            Sf9 insect cells
            287-end
            NM_000923
             
            11、高活性蛋白酶
            品名
            貨號(hào)
            種屬
            標(biāo)記類型
            表達(dá)系統(tǒng)
            氨基序列
            CPB (carboxypeptidase B), Active
            C560-31N
            Rat
            tag-free
            Yeast cells
            109-end
            EK (enterokinase), Active
            E535-31H
            Swine
            His tag
            Yeast cells
            800-end
            Immobilized Lys-c, Agarose
            L585-31AN
            Bacteria
            tag-free
            E.coli
            206-473 aa
            Immobilized Lys-c, Silica
            L585-31SN
            Bacteria
            tag-free
            E.coli
            206-473 aa
            Immobilized Thrombin, Agarose
            T565-31AN
            Human
            Native
             
             
            Immobilized Trypsin, Agarose
            T575-31AN
            Swine
            tag-free
            Yeast cells
            10-end
            Immobilized Trypsin, Silica
            T575-31SN
            Swine
            tag-free
            Yeast cells
            10-end
            KEX2 Protease, Active
            K525-31N
            Yeast
            tag-free
            Yeast cells
            110-660 aa
            Lys-c (lysyl-endopeptidase), Active
            L585-31N
            Bacteria
            tag-free
            E.coli
            206-473 aa
             
            二、抗體產(chǎn)品系列
            1、亞型特異性抗體
            品名
            貨號(hào)
            宿主
            應(yīng)用
            Anti-AKT3
            A18-63R
            Rabbit
            WB
            Anti-AMPK alpha 1
            P47-63R
            Rabbit
            WB
            Anti-CAMK1
            C07-60M
            Mouse, IgG1, 5H8
            WB
            Anti-CHK2
            C48-60M
            Mouse, IgG1, 7F9
            WB
            Anti-ERK1
            M29-60M
            Mouse, IgG1, E32
            WB, IP
            Anti-ERK1
            M29-60BM
            Mouse, IgG1, E19
            WB, IP
            Anti-GSK3 alpha
            G08-63R
            Rabbit
            WB
            Anti-GSK3 beta
            G09-60M
            Mouse, IgG1, 6C2
            WB
            Anti-HSP90 beta
            H36-63R
            Rabbit
            WB
             
            2、偶聯(lián)修飾的抗體
            品名
            貨號(hào)
            宿主
            應(yīng)用
            Anti-5-Methylated Cytosine (5-methyl cytosine)
            C92-67S
            Sheep, IgG
            WB, IP
            Anti-Acetylated Lysine
            L95-66R
            Rabbit
            WB, ELISA, PI, IHC, IF
            Anti-Acetylated Lysine, Biotin Conjugated
            L95-66BR
            Rabbit
            WB, ELISA, IF, IHC, IP
            Anti-Acetylated Lysine, FITC Conjugated
            L95-66CR
            Rabbit
            For direct immunofluorescence assay
            Anti-Acetylated Lysine, HRP Conjugated
            L95-66DR
            Rabbit
            WB, ELISA, IF, IHC, IP
            Anti-Methylated Arginine (NG, NG-Di-methyl)
            A96-67R
            Rabbit
            WB, ELISA, IF, IHC, IP
            Anti-Methylated Arginine (NG-Mono-methyl)
            A95-67R
            Rabbit
            WB, ELISA, IF, IHC, IP
            Anti-Methylated Lysine (Tri- epsilon-N-methyl)
            L95-67R
            Rabbit
            WB, ELISA, IF, IHC, IP
             
            3、磷酸化特異性抗體
            該產(chǎn)品系列共包括82款磷酸化特異性抗體，下表僅列部分產(chǎn)品，
            品名
            貨號(hào)
            宿主
            應(yīng)用
            Anti-phospho-14-3-3 beta (Ser58)
            Y71-365R
            Rabbit, IgG
            WB, IHC
            Anti-phospho-4EBP1 (Thr45)
            E35-365R
            Rabbit, IgG
            WB, IHC
            Anti-phospho-AKT1/2/3 (Ser473)
            A16-65BR
            Rabbit, IgG
            WB, IHC
            Anti-phospho-AKT1/2/3 (Thr308)
            A16-65R
            Rabbit, IgG
            WB, IHC
            Anti-phospho-ASK1 (Ser966)
            M13-65R
            Rabbit, IgG
            IHC
            Anti-phospho-ATF2 (Ser112)
            A10-565R
            Rabbit, IgG
            IHC
            Anti-phospho-ATF2 (Ser490 Ser498)
            A10-565BR
            Rabbit, IgG
            WB, IHC
            Anti-phospho-BRCA1 (Ser1423)
            B87-365R
            Rabbit, IgG
            IHC
            Anti-phospho-c-KIT (Tyr721)
            K06-65R
            Rabbit, IgG
            WB
            Anti-phospho-c-KIT (Tyr936)
            K06-65BR
            Rabbit, IgG
            IHC
             
            4、Primary Antibodies
            該產(chǎn)品系列共包括279款原初抗體，下表僅列部分產(chǎn)品
             
            品名
            貨號(hào)
            宿主
            應(yīng)用
            Anti-4EBP1
            E35-563R
            Rabbit, IgG
            WB, ELISA, ICC
            Anti-ADD1
            A38-63R
            Rabbit
            WB
            Anti-AFX
            A42-63R
            Rabbit
            WB
            Anti-AKT (pan)
            A16-63R
            Rabbit
            WB
            Anti-AKT (pan)
            A16-63BR
            Rabbit
            WB
            Anti-AKT1
            A16-60M
            Mouse, Monoclonal, 9A4
            WB
            Anti-AKT1
            A16-63CR
            Rabbit, IgG
            WB, ELISA, IF, IHC
            Anti-AKT2/3
            A17-63BR
            Rabbit
            WB
            Anti-ALK2
            A06-63R
            Rabbit, IgG
            WB, ELISA
            Anti-ALK4
            A07-63R
            Rabbit, IgG
            WB, ELISA
             
            5、二抗
            品名
            貨號(hào)
            宿主
            應(yīng)用
            Anti-Mouse HRP
            G32-62G
            Goat Polyclonal
            WB, ELISA
            Anti-Rabbit HRP
            G33-62G
            Goat Polyclonal
            WB, ELISA
             
            6、Tag標(biāo)簽抗體
            品名
            貨號(hào)
            宿主
            應(yīng)用
            Anti-DYKDDDDK
            F51-61M
            Mouse, IgG2b, FG4R
            WB, ELISA, IP, IS
            Anti-DYKDDDDK
            F51-63R
            Rabbit
            WB
            Anti-GFP
            G46-60M
            Mouse, IgG1, GF28R
            WB
            Anti-GST
            G52-61M
            Mouse, IgG2a, G2R
            WB
            Anti-HA
            H98-61M
            Mouse, IgG3, C10
            WB, ELISA, IP, IS
            Anti-HA
            H98-63R
            Rabbit Polyclonal
            WB, ELISA, IP, IS
            Anti-His
            H99-61M
            Mouse, IgG2b, EH158
            WB, ELISA, IP, IS
            Anti-His
            H99-63R
            Rabbit
            WB, ELISA, IP, IS
            Anti-Myc
            M86-61M
            Mouse, IgG1, M19
            WB, ELISA, IP, IS
            Anti-RFP
            R46-61M
            Mouse, IgG1, RF5R
            WB
            Anti-V5
            V05-61M
            Mouse, IgG1, V4RR
            WB, ELISA, IP, IS
             
            三、生物制劑產(chǎn)品系列
            1、表觀遺傳酶激活劑
            品名
            貨號(hào)
            CAS 注冊(cè)號(hào)
            分子式
            純度
            BML-278
            S35-904C
            N/F
            C24H25NO4
            >98% (TLC)
            CTPB
            P07-903
            586976-24-1
            C31H43ClF3NO2
            98%
            Resveratrol
            S35-904
            501-36-0
            C14H12O3
            >98%
            SirtAct
            S35-904E
            839699-72-8
            C20H25N5O2
            98% (TLC)
             
            2、表觀遺傳酶抑制劑
            該產(chǎn)品系列共包括33款表觀遺傳研究酶類的抑制劑，下表僅列部分產(chǎn)品
            品名
            貨號(hào)
            應(yīng)用
            2’-Deoxy-5-fluorocytidine
            D353-904D
            不可逆DNA甲基轉(zhuǎn)移酶抑制劑
            5-Azacytidine
            D353-904
            DNA低甲基化試劑
            AK-7
            S36-904
            SIRT2抑制劑
            APICIDIN
            H83-904B
            HDAC抑制劑
            BIX-01294 3HCl
            S344-903
            Histone甲基轉(zhuǎn)移酶抑制劑
            BML-210
            H83-904C
            HDAC抑制劑
            C-646
            K311-903
            HAT抑制劑
            Chaetocin
            K421-904C
            Ly甲基轉(zhuǎn)移酶抑制劑
            CPTH2
            K311-903B
            HAT 抑制劑
            3、激酶激活劑
            品名
            貨號(hào)
            CAS 注冊(cè)號(hào)
            分子式
            純度
            8-pCPT-2-O-Me-cAMP-AM
            R46-905
            1152197-23-3
            C20H21ClN5O8PS
            >97% (HPLC)
            AICAR
            P47-900B
            2627-69-2
            C9H14N4O5
            >99% (TLC); NMR (Conforms)
            4、激酶抑制劑
            該產(chǎn)品系列共包括80款常用激酶抑制劑，下表僅列部分產(chǎn)品
            品名
            貨號(hào)
            應(yīng)用
            6BIO
            G08-900
            GSK3 inhibitor
            A83-01
            A09-900
            ALK inhibitor
            AAL-993
            F11-900C
            VEGF inhibitor
            AG-1296
            P12-900
            PDGFR Inhibitor
            AG-1478
            E10-900B
            EGFR inhibitor
            AG-1517
            K11-900B
            Tyrosine kinase inhibitor
            5、磷酸酶抑制劑
            品名
            貨號(hào)
            CAS 注冊(cè)號(hào)
            分子式
            純度
            Cantharidin
            P16-902C
            56-25-7
            C10H12O4
            >98% (HPLC)
            EX-527
            S35-904F
            49843-98-3
            C13H13ClN2O
            98% (TLC)
            NSC-663284
            C04-902
            383907-43-5
            C15H16ClN3O3
            >98%
            Okadaic acid, free acid
            P16-902
            78111-17-8
            C44H68O13
            >98% (TLC)
            6、內(nèi)參siRNA
            品名
            貨號(hào)
            beta-Actin Positive Control siRNA
            A03-911D
            Cy3 Labeled Negative Control siRNA
            S02-910N
            FAM Labeled Negative Control siRNA
            S03-910N
            GAPDH Positive Control siRNA
            G13-911B
            Unlabeled Negative Control siRNA
            S01-910N
            7、激酶研究常用siRNA
            該產(chǎn)品系列共包括782款常用激酶的siRNA，下表僅列部分產(chǎn)品
            品名
            貨號(hào)
            14-3-3 alpha/beta siRNA Set I
            Y71-911
            14-3-3 epsilon siRNA Set I
            Y75-911
            14-3-3 sigma siRNA Set I
            Y86-911
            14-3-3 theta siRNA Set I
            Y84-911
            14-3-3 zeta siRNA Set I
            Y92-911
            4EBP1 siRNA Set I
            E35-911
            AATK siRNA Set I
            A02-911
            ABL1 siRNA Set I
            A03-911
            ABL2 siRNA Set I
            A04-911
            ACK siRNA Set I
            A05-911
            ACVR2A siRNA Seti
            A35-911
             
            四、信號(hào)通路蛋白及酶
            該產(chǎn)品系列包括目前常用的信號(hào)通路蛋白及相關(guān)酶類，品種多種多樣，包括：乙酰/甲基轉(zhuǎn)移酶系列、適配蛋白系列、凋亡通路系列、精氨酸脫亞氨酶系列、細(xì)胞周期蛋白系列、細(xì)胞應(yīng)激及分子伴侶蛋白系列、去乙?；?甲基化酶系列、二氫嘧啶酶系列、雙加氧酶系列、果糖激酶系列、G-蛋白家族產(chǎn)品系列、激酶突變體產(chǎn)品系列、蛋白激酶產(chǎn)品系列、脂質(zhì)氧化酶系列、微管/肌動(dòng)蛋白相關(guān)蛋白產(chǎn)品系列、磷脂酶C家族產(chǎn)品系列、超氧化物歧化酶產(chǎn)品系列、Tau蛋白及其相關(guān)產(chǎn)品系列、轉(zhuǎn)錄因子產(chǎn)品系列、泛素蛋白產(chǎn)品系列以及無(wú)活性激酶產(chǎn)品系列。
            五、信號(hào)通路相關(guān)檢測(cè)試劑
            該產(chǎn)品系列包括檢測(cè)試劑、脂類酶底物、寡氨酸底物、肽底物、蛋白酶底物等產(chǎn)品系列。
            六、胞外配體蛋白
            該產(chǎn)品系列包括細(xì)胞趨化因子、細(xì)胞因子及生長(zhǎng)因子（生長(zhǎng)因子共134種，下表僅列部分）。
            品名
            貨號(hào)
            應(yīng)用
            IP-10
            I838-40N
            Cell Assay
            RANTES (CCL5)
            R801-40N
            Cell Assay
            SDF-1
            S821-40N
            Cell Assay
            IFN-gamma
            I837-40N
             
            TNF-alpha
            T860-40N
             
            TNF-beta
            T861-40BG
             
            TNFB
            T861-40N
             
            TRAIL
            T880-40N
             
             
            SLC中國(guó)代理商上海起發(fā)實(shí)驗(yàn)試劑有限公司，是專業(yè)從事生命科學(xué)研究領(lǐng)域產(chǎn)品代理及部分生 物產(chǎn)品自主研發(fā)，以為科研人員提供高品質(zhì)科研產(chǎn)品為己任，是您值得信賴的科研伙伴！
             
             
             
          
            
        
            


         
            
        
        
            
  
            

            

            

            






             
     

            






 
  


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